The Sinclair sisterhood is about to be rocked from its foundation when Meg-the bedrock sibling most like Momma-collapses with a brain tumor. Surgery removes the invading mass but leaves a sister full of mood swings, depression, anger, and bitterness. Tandy, Kendra, and Joy struggle to find a trace of their formerly happy sister, who always pointed them to life's positives. Meg's husband, Jamison, struggles even more. With no idea how to handle the new, unimproved person inhabiting his wife's body, he finds it too easy to seek solace in the clever conversation of another woman. What none of them realize is that the wisdom they need is already at hand.