Nurse Levee O'Reilly and her husband, Dr. Liam O'Reilly, are headed west to the California Territory to practice medicine when their stagecoach is tragically attacked by the infamous Frank Michaels. All alone now and grieving, Levee makes her way to Eagle Pass, Texas. The local doctor can't afford to pay a staff nurse, however, and so she turns to the only other option-teaching. Devoted wholeheartedly to her students, Levee has little time for romance.
Deep down, Daniel Neville wants to be a preacher, but he's battled doubts and distrust for most of his life. Wracked with guilt over his twin sister's death and then "punished" with a limp from an injury sustained during a stampede, Dan dedicates himself instead to serving his family and working with horses on their ranch. Marriage is far from the top of his to-do list, and he aims to keep it that way.